Phthalate Induction of CYP3A4 is Dependent on Glucocorticoid Regulation of PXR Expression
نویسندگان
چکیده
منابع مشابه
Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression.
Cytochrome P450 3A4 (CYP3A4) is responsible for oxidative metabolism of more than 60% of all pharmaceuticals. CYP3A4 is inducible by xenobiotics that activate pregnane X receptor (PXR), and enhanced CYP3A4 activity has been implicated in adverse drug interactions. Recent evidence suggest that the widely used plasticizer, di-2-ethylhexyl phthalate (DEHP), and its primary metabolite mono-2-ethylh...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2008
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfn047